I have Asperger's Syndrome and I'm really getting sick and tired of being misunderstood. What should I do?

Show her this letter, and now that you know what the cause is, you can get more info on the condition, and have your wife read up on it as well. She may also need to talk to someone about it. Now she has to come to terms with the fact that you're not just a jerk, there's a legitimate reason for your behavior, and she also has to realize it's not something that can go away. There may actually be a sort of grieving period involved. And you don't owe anyone an apology. Any apologies should be to you. Get all the information you can on the condition and share it with your wife and friends, so they can understand you better. If you know you have offended her, even if you don't understand how, say you're sorry she's upset, and try to avoid doing whatever again. Good luck with everything.